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研究業績

  2013年 2016年
  2013年 2015年
  2013年 2014年
  2013年 2013年
  2012年 2012年
  2011年 2011年
  2010年 2010年
  2009年 2009年
  2008年 2008年
  2001年~2007年 2001年~2007年

2016年

Sasaki S, Baba T, Nishimura T, Hayakawa Y, Hashimoto S, Gotoh N, Mukaida N.: Intra-bone fibroblasts promote breast cancer bone metastasis by producing connective tissue growth factor/CCN2 under the influence of cancer cell-derived chemokine, CCL4. Cancer Lett, 378, 23-32, 2016.


Murayama T, Nakaoku T, Enari T, Nishimura T, Tominaga K, Nakata A, Tojo A, Sugano S, Kohno T, Gotoh N.: Oncogenic fusion gene CD74-NRG1 confers cancer stem cell-like properties in lung cancer through a IGF2 autocrine/paracrine circuit, Cancer Res, 76, 974-983, 2016.



2015年

Hasegawa S, Nagano H, Konno M, Eguchi H, Tomokuni A, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Marubashi S, Nishida N, Koseki J, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H.: Cyclin G2: A novel independent prognostic marker in pancreatic cancer. Oncol Lett, 10, 2986-2990, 2015.


Konno M, Ishii H, Koseki J, Tanuma N, Nishida N, Kawamoto K, Nishimura T, Nakata A, Matsui H, Noguchi K, Ozaki M, Noguchi Y, Shima H, Gotoh N, Nagano H, Doki Y, Mori M.: Pyruvate Kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells. Regenerative Therapy, 1, 63-71, 2015.


Gotoh N and Tsuchida N.: Membrane-linked docking protein. Encyclopedia of Cancer, 3rd Edition, Springer, Heidelberg, Germany, in press.


Ogawa H, Wu X, Kawamoto K, Nishida N, Konno M, Koseki J, Matsui H, Noguchi K, Gotoh N, Yamamoto T, Miyata K, Nishiyama N, Nagano H, Yamamoto H, Obika S, Kataoka K, Doki Y, Mori M, Ishii H.: MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells. PLoS One, 10, e0127119, 2015. doi: 10.1371/journal.pone.0127119.


Konno M, Koseki J, Kawamoto K, Nishida N, Matsui H, Dewi DL, Ozaki M, Noguchi Y, Mimori K, Gotoh N, Tanuma N, Shima H, Doki Y, Mori M, Ishii H: Embryonic MicroRNA-369 controls metabolic splicing factors and urges cellular reprogramming. PLoS One, 10, e0132789, 2015.


Nadal E, Truini A, Nakata A, Lin J, Reddy RM, Chang A, Ramnath N, Gotoh N, Beer DG, Chen G: A novel serum 4-microRNA signature for lung cancer detection. Sci Rep, 5, 12464, 2015. doi: 10.1038/srep12464.


Nakata A, Yoshida R, Yamaguchi R, Yamauchi M, Tamada Y, Fujita A, Shimamura T, Imoto S, Higuchi T, Nomura M, Kimura T, Nokihara H, Higashiyama K, Kondoh K, Nishihara H, Tojo A, Yano S, Miyano S, Gotoh N.: Elevated beta-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs. Sci Rep, 5, 13076, 2015. doi: 10.1038/srep13076.



2014年

Shima T, Miyamoto T, Kikushige Y, Yoda J, Tochigi T, Yoshimoto G, Kato K, Takenaka K, Iwasaki H, Mizuno S, Goto N, Akashi K.: The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell. Exp Hematol, 42, 955-965, 2014.


Hasegawa S, Eguchi H, Nagano H, Konno M, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Nishida N, Koseki J, Nishimura T, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H.: MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer. Br J Cancer, 111, 1572-80, 2014.


Kohsaka S, Hinohara K, Wang L, Nishimura T, Urushido M, Yachi K, Tsuda M, Tanino M, Kimura T, Nishihara H, Gotoh N, Tanaka S.: Epiregulin enhances tumorigenicity activating ERK/MAPK pathway in glioblastoma. Neuro Oncol, 16, 960-70, 2014.


Ono K, Kita T, Sato S, O’Neill P, Mak S-S., Paschaki M, It, M, Gotoh, N, Kawakami K, Ladher RK.: Fgfr1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation. PLoS Genetics, 10, e1004118, 2014.


Li H, Ta, C, Cai Z., Hertzler-Schaefer K, Collins TN, Wang F, Feng G-S, Gotoh N, Zhang X.: Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci, 127, 571-582, 2014.


Li H, Ta, C, Cai Z., Hertzler-Schaefer K, Collins TN, Wang F, Feng G-S, Gotoh N, Zhang X.: Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci, 127, 571-582, 2014.



2013年

Tomokuni A, Eguchi H, Hoshino H, Dewi DL, Nishikawa S, Kano Y, Miyoshi N, Tojo A, Kobayashi S, Gotoh N, Hinohara K, Fusaki N, Saito T, Suemizu H, Wada H, Kobayashi S, Marubashji S, Tanemura M, Doki Y, Mor, M, Ishii H, Nagano H. Effect of in vivo administration of reprogramming factors in the mouse liver. Oncol Lett, 6, 323-328, 2013.


Gotoh N.: Growth factor signaling regulates breast cancer stem cells. In Practical molecular target for suppression of cancer. Publication in Forum on Immunopathological Diseases and Therapeutics, Begell House Inc. Publisher, CT, USA, 4, 2013.


Hashimoto M, Suizu F, Tokuyama W., Noguchi H, Hirata N, Matsuda-Lennikov M, Masuzawa M, Gotoh, N, Tanaka S. & Noguchi M.: Protooncogene TCL1b functions as an Akt kinase co-activator which exhibits oncogenic potency in vivo. Oncogenesis, 2, e70, doi: 10.1038/oncsis.2013.30.


Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F. & Zhang X.: Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development, 140, 2711-2723, 2013.


Kano Y, Tsuchiya K, Zheng X, Horita N, Fukushima K, Hibiya S, Yamauchi Y, Nishimura T, Hinohara K, Gotoh N, Suzuki S, Okamoto R., Nakamura T. & Watanabe M.: The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. Biochem Biophys Res Commun, 432, 175-181, 2013.


Minegishi Y, Shibagaki Y, Mizutani A, Fujita F, Tezuka T, Kinoshita M, Kuroda M, Hattori S. & Gotoh N.: An adaptor protein complex of FRS2beta and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation. Cancer Sci, 104, 345-352, 2013.



2012年

Ohno, S., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A, Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., Gotoh, N., Kuroda, M.:
Systemically injected exosomes targeted to EGFR deliver anti-tumor microRNA to breast cancer cells. Molecular Therapy, 21, 185-191, 2012.


Yamauchi, M., Yamaguchi, R., Nakata, A., Kohno, T., Nagasaki, M., Shimamura, T., Imoto S., Saito A., Ueno, K., Hatanaka, Y., Yoshida, R., Higuchi, T., Nomura, M., Beer, D.G., Yokota, J., Miyano, S. & Gotoh, N.:Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma. PLoS ONE, 7, e43923, 2012.


Nakata, A. & Gotoh, N.:
Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer. Expert Opin. Ther. Targets, 16, 771-781, 2012.


Kojima, K., Imoto, S., Yamaguchi, R., Fujita, A., Yamauchi, M., Gotoh, N. & Miyano, S.: Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing. BMC Genomics, Suppl. 1, S6, 2012.


Hinorara, K., Kobayashi S., Kanauchi, H., Shimizu, S., Nishioka, K., Tsuji, E., Tada, K., Umezawa, K., Mori, M., Ogawa, T., Inoue, J., Tojo, A. & Gotoh, N.: ErbB/NF-kB signaling controls mammosphere formation in human breast cancer. Proc. Natl. Acad. Sci., USA, 109, 6584-6589, 2012.



2011年

Okayama, H., Khono, T., Ishii, Y., Shimada, Y., Shiraishi, K., Iwakawa, R., Furuta, K., Tsuta, K., Shibata, T., Yamamoto, S., Watanabe, S., Sakamoto, H., Kumamoto, K., Takenoshita, S., Gotoh, N., Mizuno, H., Sarai, A., Kawano, S., Yamaguchi, R., Miyano, S. & Yokota, J.:
Identification of genes up-regulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinoma. Cancer Res., 72; 100-111, 2011.


Nomura, M., Fukuda, T, Fujii, K., Kawamura, T., Tojo, H., Kihara, M., Bando, Y., Gazdar, A.F., Tsuboi, M., Oshiro, H., Nagao, T., Ohira, T., Ikeda, N., Gotoh, N., Kato, H., Marko-Varga, G. & Nishimura, T.: Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. Journal of Clinical Bioinformatics, 1; 23, (3 September), 2011.


Yamauchi, M., Yoshino, I., Yamaguchi, R., Shimamura, T., Nagasaki, M., Imoto, S., Niida, A., Koizumi, F., Kohno, T., Yokota, J., Miyano, S. & Gotoh, N.: N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells. Am. J. Cancer. Res., 1; 823-833, 2011.



Gotoh, N.: Somatic mutations of the EGF receptor and their signal transducers affect the efficacy of EGF receptor-specific tyrosine kinase inhibitors. Int. J. Clin. Exp. Pathol., 4; 403-409, 2011.



Nasirujjaman K., Kimura-Yoshida, C., Gotoh, N., Hiramatsu, R. and Matsuo I.: A genetic study of the effects of reduced Frs2alpha gene dosage in exostoses development and cartilage abnormalities observed in Ext2 heterozygous mutant mice. Journal of Osaka Medical Center & Research Institute for Maternal & Child Health., 26; 101-108, 2011.



Gotoh,N.:FRS2. In:Encyclopedia of Signaling Molecules.Springer,Heidelberg,Germany.




2010年

Oyama, M., Nagashima, T., Suzuki, T., Kozuka-Hata, H., Yumoto, N., Shiraishi, Y., Ikeda, K., Kuroki, Y., Gotoh, N., Ishida, T., Inoue, S., Kitano, H., Okada-Hatakeyama, M.: Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer. J. Biol. Chem., 286; 818-829, 2010.



Tasaki, S., Nagasaki, M., Kozuka-Hata, H., Semba, K., Gotoh, N., Hattori, S., Inoue, J., Yamamoto, T., Miyano, S., Sugano, S. and Oyama, M. : Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling. PLoS ONE, 5(11); e13926, 2010.



Gotoh, N.: Possible signaling pathways in cancer stem cells in breast cancer. In: Cancer Stem Cells, Nikolic, A. (Ed.), ITECH, Vienna, Austria.



Hinohara, K. and Gotoh, N.: Inflammatory signaling pathways in self-renewing breast cancer stem cells. Curr. Opin. Pharmacol., 10; 650-654, 2010.
(論文の図がこの号の表紙に採用されました)



Shimamura, T., Imoto, S., Nagasaki, M., Yamauchi, M., Yamaguchi, R., Fujita, A., Tamada, Y., Gotoh, N., Miyano, S. Collocation-based sparse estimation for constructing dynamic gene networks. Genome Inform., 24: 164-178, 2010.



Sato, T., Shimazaki, T., Naka, H, Fukami, S., Okano, H., Lax, I., Schlessinger, J. and Gotoh, N.: FGF-FRS2a-Erk axis controls a self-renewal target Hes1 and growth of neural stem/progenitor cells. Stem Cells., 28: 1661-1672, 2010.



Kojima, K., Yamaguchi, R., Imoto, S., Yamauchi, M., Nagasaki, M., Yoshida, R., Shimamura, T, Ueno, K., Higuchi, T., , Gotoh, N., Miyano, S.: A state space representation of VAR models with sparse learning for dynamic gene networks. Genome Inform., 22, 56-68, 2010.



Iejima, D., Minegichi, Y., Takenaka, K., Siswanto, A., Watanabe, M., Huang, L., Watanabe, T., Tanaka, F., Kuroda, M. and Gotoh, N.: FRS2b, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor for EGF receptor family members via ERK binding. Oncogene, 29: 3087-3099, 2010.



Murohashi, M., Hinohara, K., Kuroda, M., Isagawa, T., Tsuji, S., Kobayashi, S., Umezawa, K., Tojo, A., Aburatani, H. and Gotoh, N.: Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells. British J. Cancer, 102: 206-212, 2010.



Murohashi, M., Nakamura, T., Tanaka, S., Ichise, T., Yoshida, N., Yamamoto, T., Shibuya, M., Schlessinger, J. and Gotoh, N.: An FGF4-FRS2a-Cdx2 axis-in trophoblast stem cells induces BMP4 to regulate proper growth of early mouse embryos. Stem Cells, 28: 113-121, 2010.




2009年

Sanada, M., Suzuki, T., Shih, L.-Y., Otsu, M., Kato, M., Yamazaki, S., Tamura, A., Honda, H., Sakata-Yanagimoto, M., Kumano, K., Oda, H., Yamagata, T., Takita, J., Gotoh, N., Nakazaki, K., Kawamata, N., Onodera, M., Nobuyoshi, M., Hayashi, Y., Harada, H., Kurokawa, M., Chiba, S., Mori, H., Ozawa, K., Omine, M., Hirai, H., Nakauchi, H., Koeffler, P. and Ogawa, S.: Gain-of-function of mutated c-Cbl tumor suppressor in myeloid neoplasms with 11q uniparental disomy. Nature, 460, 904-909, 2009.



Iejima, D. and Gotoh, N.: FRS2b docking/scaffolding adaptor protein. Current research in cancer, Research Media, India,3, 99-107, 2009.



Kameda, Y., Ito, M., Nishimaki, T. and Gotoh, N.: FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus. Dev. Dyn., 238, 503-513, 2009.



Yamauchi, M., and Gotoh, N.: Molecular mechanisms determining efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates. Biomark. Med., 3, 139-151, 2009.



Minegishi, Y., and Gotoh, N.: Frs2beta. Nature Molecule Pages doi:10.1038/mp.a004122.01, 2009.



Minegishi, Y., Iwanari, H., Mochizuki, Y., Horii, T., Hoshino, T., Kodama, T., Hamakubo, T. and Gotoh, N.: Prominent expression of FRS2b protein in neural cells and its association with intracellular vesicles. FEBS lett., 583, 807-814, 2009.



Sato T. and Gotoh, N.: The FRS2 family of docking/scaffold adaptor proteins as therapeutic targets of cancer treatment. Expert Opinion on Therapeutic Targets, 13, 689-700, 2009.



Sato, T. and Gotoh, N.: Frs2alpha. Nature Molecule Pages,
doi:10.1038/mp.a000967.01, 2009.



Gotoh, N.: Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells. Current Stem Cell Research & Therapy, 4, 9-15, 2009.



Gotoh, N.: Feedback inhibitors of epidermal growth factor receptor signaling pathways. Int. J. Biochem. Cell Biol., 41, 511-515, 2009.




2008年

Yamaguchi, R., Imoto, S., Yamauchi, M., Nagasaki, M., Yoshida, R., Shimamura, T., Hatanaka, Y., Ueno, K., Higuchi, T., Gotoh, N. and Miyano, S.: Predicting differences in gene regulatory systems by state space models. Genome Infomatics, 21, 101-113, 2008.



Gotoh, N.: Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins. Cancer Sci., 99, 1319-1325, 2008.



Kameda, Y., Ito, M., Nishimaki T. and Gotoh, N.: FRS2a2F/2F mutant mice lack the carotid body and exhibit sympathetic ganglia and carotid sinus nerve abnormalities. Dev. Biol., 314, 236-247, 2008.



Gotoh, N. and Tsuchida, N.: Membrane-linked docking protein. Encyclopedia of Cancer, 2nd Edition, Springer, Heidelberg, Germany, 1819-1823, July 4, 2008.




2001年~2007年

Kang, E.S., Oh, M.A., Lee, S.A., Kim, T.Y., Kim, S.H., Gotoh, N., Kim, Y.N. and Lee, J.W.: EGFR phosphorylation-dependent formation of cell-cell contacts by Ras/Erks cascade inhibition. Biochim. Biophys. Acta., 1773, 833-843, 2007.



Huang, L., Watanabe, M., Chikamori, M., Kido, Y., Yamamoto, T., Shibuya, M., Gotoh, N. and Tsuchida, N.: Unique role of SNT-2/FRS2b/FRS3 docking/adaptor protein for negative regulation of EGF receptor tyrosine kinase pathways. Oncogene, 25, 6457-6466, 2006.
(Gotoh, N. and Tsuchida, N. contributed equally to this work.)



Yamamoto, S., Yoshino, I., Shimazaki, T., Murohashi, M., Hevner, R. F., Lax, I., Okano, H., Shibuya, M., Schlessinger, J. and Gotoh, N.: Essential role of Shp2-binding sites on the docking protein FRS2a for mamalian corticogenesis and for FGF2-dependent proliferation of cultured neural progenitor cells. Proc. Natl. Acad. Sci., USA, 102, 15983-15988, 2005.



Gotoh, N., Manova, K., Tanaka, S., Murohashi, M., Hadari, Y., Lee, A., Hamada, Y., Hiroe, T., Ito, M., Kurihara, T., Nakazato, H., Shibuya, M., Lax, I., Lacy, E. & Schlessinger, J.: The docking protein FRS2a is an essential component of multiple FGF responses during early mouse development. Mol. Cell. Biol, 25, 4105-4116, 2005.



Gotoh, N., Ito, M., Yamamoto, S., Yoshino, I., Song, N., Wang, Y., Lax, I., Schlessinger, J., Shibuya, M. & Lang, R. A.: Tyrosine phosphorylation sites on FRS2a responsible for Shp2 recruitment are critical for induction of lens and retina. Proc. Natl. Acad. Sci. USA, 101, 17144-17149, 2004.



Huang, L., Gotoh, N., Zhang, S., Shibuya, M., Yamamoto, T. & Tsuchida, N.: SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. Biochem. Biophys. Res. Commun., 324, 1011-1017, 2004.



Gotoh, N., Laks, S., Nakashima, M., Lax, I. & Schlessinger, J.: FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. FEBS lett., 564, 14-18, 2004.



Nakamura, T., Komiya, M., Sone, K., Hirose, E., Gotoh, N., Morii, H., Ohta, Y. & Mori, N.: Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and Crk/Crk adapter molecules. Mol. Cell. Biol., 22, 8721-8734, 2002.



Maida, Y., Kyo, S., Kanaya T., Wang, Z., Takakura, M., Yatabe, N., Tanaka, M., Nakamura, M., Hisamoto, K., Ohmichi, M., Gotoh, N. & Inoue, M.: EGF directly activates telomerase via Ets-mediated transactivation of TERT through MAP kinase signaling pathway. Oncogene, 21, 4071-4079, 2002.



Nakamura, T., Komiya, M., Gotoh, N., Koizumi, S., Shibuya, M. & Mori, N.: Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adaptor molecules. Oncogene, 21, 22-31, 2002.



Onishi-Haraikawa, Y., Funaki, M., Gotoh, N., Shibuya, M., Inukai, K., Katagiri, H., Fukushima, Y., Anai, M., Ogihara, T., Sakoda, H., Ono, H., Kikuchi, M., Oka, Y. & Asano, T.: Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein. Biochem. Biophys. Res. Commun., 288, 476-482, 2001.



Hadari, YR., Gotoh, N., Kouhara, H., Lax, I. & Schlessinger, J. : Critical role for docking protein FRS2a in FGF-receptor mediated signal transduction. Proc. Natl. Acad. Sci. USA, 98, 8578-8583, 2001.



Ong, SH., Hadari, YR., Gotoh, N., Guy, GR., Schlessinger, J. & Lax, I.: Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc. Natl. Acad. Sci. USA, 98, 6074-6079, 2001.



Xue, Y., Wang, X., Li, Z., Gotoh, N., Chapman, D. & Skolnik, EY.: Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK). Development, 128, 1559-1572, 2001.




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